Critically ill patients are at high risk for developing a life-threatening infection such as bloodstream infection or pneumonia. These infections might lead to sepsis and multiple organ failure. Adequate antimicrobial therapy is essential to optimize the chances of survival. Three key issues in this regard are (i) a first antimicrobial dose administered as soon as possible after the onset of the septic episode, (ii) an empiric antimicrobial spectrum covering the causative pathogens, and (iii) adequate dosing. However, efficient dosing is problematic because of pathophysiological changes associated with critical illness affects the pharmacokinetics of mainly hydrophilic antimicrobials. And the preparation and administration of antibiotics may also negatively impact the efficiency of therapy. Therefore nurses must be aware of some points of interest in order to optimize antibiotic therapy.
By the end of this webinar, the attendee will be able to:
1. Describe the essential pillars of antimicrobial therapy
2. Understand why and how these pillars affect survival
3. Describe the basics of pharmacodynamics of antimicrobial agents in sepsis
4. Apply insights in pharmacodynamics to optimise antimicrobial therapy
This lecture is equal to 1 CE Contact Hour and 1 CPD Hour
Duration 60 mins.
Prof. Stijn Blot
Stijn Blot is research professor at Ghent University and honorary professor at The University of Queensland. His research focus is on various aspects of healthcare-associated infections in critically ill patients. He is unique through his varied background that allows bridging distinct disciplines and interpreting clinical data in an exclusive way. He succeeded to consolidate a solid reputation in research and established a firm international network of collaborators. He is editor of 12 books, (co-) author of 40 books/book chapters and 287 publications indexed in the Web of Science adding to a h-index of 56. His research is acknowledged with multiple national and international awards and in 2015 he was inducted in the International Nurse Researcher Hall of Fame of the STTI Honor Society of Nursing.