Acute Muscle Wasting in the ICU

A review of the literature

The lecture duration is 28min.

0.5 CPD Points, 0.5 CEUs, 0.5 AMA PRA Category 1 Credits.
Accredited by CPDUK, CBRN and EB Medicine.

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Dr Zudin Puthucheary
Senior Lecturer in Critical Care at the William Harvey Research Institute, London
Lecture Summary

Acute muscle wasting occurs rapidly in the critically ill patient, at rates of 2-3% per day, and is associated with levels of organ failure. Muscle wasting is associated with adverse outcomes at all stages of critical illness and critical illness recovery, affecting mortality up to 1 year later. Altered muscle protein homeostasis (and specifically depressed muscle protein synthesis) underpins this process and is in turn underpinned by bioenergetic failure and intramuscular inflammation. This talk will cover the underpinning biology, the potential role of exercise and nutrition in amelioration and treatment, and several ongoing trials in the field of acute muscle wasting.

Target Audience

Critical Care Doctors
Experienced or advanced Critical Care Nurses

Learning Objectives:

Upon completion of this activity, you should be able to:

  • Understand the physiology underpinning acute muscle wasting
  • Understand the modulators of muscle protein homeostasis
  • Interpret future trials of exercise and nutrition to treat functional disability
  • Describe ongoing clinical trials in the field

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of EB Medicine and Continulus. EB Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation

EB Medicine designates this internet-enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Needs Assessment

The need for this educational activity was determined by surveys of the target audience and experts in the specialty. Further assessment was provided by examining the topics of recently published evidence-based medicine reviews, national clinical guidelines, and specialty society recommendations, as well as suggestions from evaluations of previous learning programs to determine practice gaps.

CME Faculty Disclosure

It is the policy of EB Medicine to ensure objectivity, balance, independence, transparency, and scientific rigor in all CME-sponsored educational activities. All faculty participating in the planning or implementation of a sponsored activity are expected to disclose to the audience any relevant financial relationships and to assist in resolving any conflict of interest that may arise from the relationship. In compliance with all ACCME accreditation requirements and policies, all faculty for this CME activity were asked to complete a full disclosure statement. The speaker did not report any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) discussed in this educational presentation.

Earning Credit

In order to earn CME credit, the participant must take the pre-test, watch the course, take the CME post-test, and complete the post-test evaluation.

Hardware/Software Requirements

Online learners will need a computer or web-enabled device to access the podcast, additional learning materials, and CME test.

Commercial Support

This activity received no commercial support.