Candida Sepsis

How to Improve Outcome

The lecture duration is 18min.

0.5 CPD Points, 0.5 CEUs, 0.5 CME credits approval pending.
Accredited by CPDUK, CBRN and Provider Pending.

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Prof. Arunaloke Chakrabarti
Director, Doodhdhari Burfani Hospital & Research Centre, Haridwar Past-President, International Society for Human & Animal Mycology Ex-Head & Professor, Medical Microbiology, PGIMER, Chandigarh, India
Lecture Summary

To improve the outcome of Candida sepsis, early diagnosis and its distinction from bacterial sepsis is of paramount importance. Despite the improvement of diagnosis in recent years with the introduction of T2 magnetic resonance nano-particle-based and MALDI-TOF techniques, a considerable number of patients are usually treated empirically due to poor sensitivity and long turnaround time of conventional technique. Antifungal prophylaxis should be restricted to the cohorts of high-risk (>10%) of Candida sepsis. The patients with positive clinical predictive values and long-stay in intensive care units, acute necrotizing pancreatitis, and recurrent gastrointestinal perforations are some of those high-risk groups. While choosing antifungal for empiric or targeted therapy, preference should be given to fungicidal (echinocandins, polyenes) drugs. However, species identification and antifungal susceptibility testing would help to choose the right drug. The other issues including early central venous catheter removal, ophthalmic examination in second week, therapeutic drug monitoring require serious attention, though deprived of consensus regarding the need and optimal time for the procedure. Finally, the delivering antimicrobial stewardship agenda will not be possible without improvement of diagnosis of Candida sepsis.

Target Audience

Emergency Medicine Doctors
Emergency Medicine Nurses
Paramedics
Rural GP's

Learning Objectives:

Upon completion of this activity, you should be able to:

  • Able to identify the dilemmas in Candida sepsis management
  • Able to identify the right drugs and targeted patients’ cohorts while using prophylaxis, empiric, and targeted therapy
  • Able to identify the gaps in knowledge in management of Candida sepsis

None.