Late Effects in Childhood Cancer

A review

The lecture duration is 28min.

0.5 CPD Points, 0.5 CEUs, 0.5 CME credits approval pending.
Accredited by CPDUK, CBRN and Provider Pending.

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Eugenia Trigoso
Specialist paediatric nurse and volunteer nurse at Barretstown, Ireland
Lecture Summary

“Late effects” are defined as therapy-related complications or adverse effects that persist or arise after completion of treatment for a paediatric malignancy. “Paediatric malignancies” are defined as those malignancies commonly associated with the paediatric population that may arise during childhood, adolescence, or young adulthood. Therapeutic interventions for a specific paediatric malignancy may vary considerably based on the patient’s age, presenting features, and treatment era. ( COG LTFU Guidelines ) About 1 in 715 young adults is a survivor of childhood malignancy. Survival is at increased risk of considerable treatment-related morbidity or even mortality as a result of late adverse effects of their treatment. At least 60% have one or more chronic health problems and about 20% had three or more. The range of late effects encountered is very wide, affecting any organ, system, tissue or function, with variable aetiology severity and complexity and may encompass psychological problems including difficulties with interpersonal relationships and post-traumatic stress disorder. More intensively treated patients may develop late toxicity even more frequently, as exemplified by survivors of haemopoietic stem cell transplantation (HSCT), of whom .90% had at least one late effect and .70% had at least three. Multidisciplinary teams including paediatric and adult oncologists, specialists in internal medicine, nurses , social workers, psychologists more experts for psychosocial care as well as specialists from other disciplines provide all required consultations so that the patients can receive treatment in a single institution.

Target Audience

Oncology nurses
Trainee oncology doctors
General practitioners

Learning Objectives:

Upon completion of this activity, you should be able to:

  • Appreciate the late effects of cancer and the need for long-term follow-up
  • List some common late effects after childhood cancer treatment and hematopoietic stem cell transplant (HSCT)
  • Understand the unmet needs of childhood cancer survivors

None.