Sepsis Pharmacology

Fluids

The lecture duration is 17min.

0.5 CPD Points, 0.5 CEUs, 0.5 CME credits approval pending.
Accredited by CPDUK, CBRN and Provider Pending.

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Matthew Semler
Assistant Professor of Medicine and Biomedical Informatics in the Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
Lecture Summary

The administration of intravenous fluid is a fundamental therapy for the treatment of patients with sepsis. This talk reviews the physiologic principles that underlie fluid therapy and sepsis, the composition and optimal choice fluid in sepsis, and data from randomized trials optimal dose of IV fluid in each phase of critical illness. Learners will understand the 3 compartment model of body fluid, information on how fluid and large molecules move from the plasma to the interstitium, and the classical understanding of the relationship between intracardiac pressures and cardiac output. They will be able to describe the composition of each available IV fluid and identify data from randomized trials as to why balanced crystalloids may improve outcomes in sepsis compared to saline and why hydroxyethylstarch may increase the risks of acute kidney injury and death in sepsis. Learners will review the four phases of fluid therapy and what interventions are associated with improved patient outcomes in each phase.

Target Audience

All doctors and nurses

Learning Objectives:

Upon completion of this activity, you should be able to:

  • Describe the physiologic principles underlying fluid therapy
  • Apply data from randomized trials to choose the optimal fluid composition for critically ill adults with sepsis
  • Understand the four phases model of fluid therapy

None.